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BAY 1251152

CAS No. 1610358-56-9

BAY 1251152 ( +)-BAY 1251152 )

Catalog No. M12323 CAS No. 1610358-56-9

BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BAY 1251152
  • Note
    Research use only, not for human use.
  • Brief Description
    BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM.
  • Description
    BAY 1251152 is the first potent, selective, orally available PTEFb/CDK9 inhibitor with biochemical IC50 of 9 nM and MOLM13 cell IC50 of 29 nM, displays> 50-fold selectivity against other CDKs;exhibits broad anti-proliferative activity against a panel of tumour cell lines with sub-micromolar IC50 values; demonstrates excellent efficacy in xenograft models (e.g. MOLM13) in mice and rats.Blood Cancer Phase 1 Clinical
  • Synonyms
    +)-BAY 1251152
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    1610358-56-9
  • Formula Weight
    404.44
  • Molecular Formula
    C19H18F2N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 113.3 mg/mL. 280.15 mM
  • SMILES
    N=S(CC1=CC(NC2=NC=C(F)C(C3=CC=C(F)C=C3OC)=C2)=NC=C1)(C)=O
  • Chemical Name
    (+)-5-Fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]pyridin-2-yl]pyridin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ulrich T. Luecking, et al. Abstract 984: Identification of potent and highly selective PTEFb inhibitor BAY 1251152 for the treatment of cancer: from p.o. to i.v. application via scaffold hops. DOI: 10.1158/1538-7445.
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